AICAR

AICAR

• Formal Name: 5-amino-1-β-D-ribofuranosyl-1H-imidazole-4-carboxamide
• Synonyms: Acadesine, AICA-Riboside, NSC 105823
• Molecular Formula: C₉H₁₄N₄O₅
• Molecular Weight: 258.2 g/mol
• Purity: ≥98% (research-grade)

Key Features

• AMPK Activation: AICAR stimulates AMP-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.
• Metabolic Research: Used to study glucose uptake, fatty acid oxidation, and insulin signaling.
• Cancer Biology: Shown to enhance the efficacy of rapamycin, suppress HER2/EGFR2 signaling, and reduce tumor cell growth in certain models.
• Cardiovascular Studies: Demonstrates vasodilation effects and lowers mean arterial pressure in animal models.
• Anti-inflammatory Potential: Exhibits anti-diabetic, antihypertensive, and anti-inflammatory activities.

Usage & Handling

• Form: Supplied as a lyophilized powder.
• Preparation: Typically reconstituted in sterile water; heating to 37°C and vortexing may be required for full solubility.
• Working Concentrations: Commonly used at 0.5–2 mM for 30 minutes to 24 hours in vitro.
• Storage: Store at -20°C, protected from light.

Important Notes

• For Research Use Only: Not intended for human or animal therapeutic use.
• Applications: Restricted to laboratory experiments in cell biology, endocrinology, metabolism, and related fields.
• Safety: Handle with appropriate protective equipment; consult the product’s Safety Data Sheet (SDS) before use.