Cagrilintide 5mg + Semaglutide 5mg – Research Grade Peptide

Cagrilintide + Semaglutide (CagriSema) is a dual-peptide research combination studied for its synergistic role in appetite regulation, energy homeostasis, and metabolic control. Cagrilintide is a long-acting amylin analogue acting on AMY1–AMY3 receptors via brainstem satiety pathways, while semaglutide is a GLP-1 receptor agonist that increases insulin secretion, suppresses glucagon release, and slows gastric emptying. Together, their complementary and non-overlapping mechanisms of action are the subject of active investigation in obesity and type 2 diabetes research models.

Research into CagriSema’s effects on metabolic processes offers insights into potential applications in the study of obesity, type 2 diabetes, and related cardiometabolic conditions across various preclinical and clinical models. Phase 3 REDEFINE trials have documented a mean body weight reduction of 22.7% at 68 weeks with CagriSema, exceeding outcomes for either monotherapy. Preclinical investigations in diet-induced obese rat models have further documented improvements in insulin sensitivity attributable to the combination.

Usage and Storage

Supplied in a lyophilised form for stability. CagriSema requires careful handling for reconstitution and storage, as detailed on our website. We recommend using bacteriostatic water as the reconstitution solvent to reach ambient laboratory temperature before reconstitution. This helps maintain structural integrity of both peptides during dissolution. Reconstitution solutions are supplied separately.

Legal and Safety Information

All Pure Peptides products, including Cagrilintide + Semaglutide, are sold exclusively for scientific and research purposes. Enquiries about human consumption are strictly prohibited. This product has not been evaluated by the FDA and is not approved for therapeutic, diagnostic, or clinical application.

Technical Data

Identification

Property	Value
Molecular Weight (Cagrilintide)	~4,531 g/mol
Molecular Weight (Semaglutide)	~4,113 g/mol
Peptide Class (Cagrilintide)	Long-acting amylin analogue, 39 amino acids, fatty-acid conjugated (DACR agonist)
Peptide Class (Semaglutide)	GLP-1 receptor agonist, 31 amino acids, fatty-acid conjugated

Physical and Chemical Properties

Property	Value
Physical Appearance	White lyophilised solid
Form	Sterile filtered white lyophilised (freeze-dried)
Solubility	Aqueous soluble (bacteriostatic water recommended)

Analytical and Quality Control

Property	Value
HPLC Result	Shows min 99% Purity
Mass Spectrum	Consistent with structure
Purity %	>99%

Research Use and Safety

Property	Value
Caution	Research use only / Not for human or veterinary use

Storage, Handling and Stability

Property	Value
Storage Temperature	Lyophilised peptides although stable at room temperature for 3 months, should be stored desiccated below −18°C. Upon reconstitution the peptide should be stored at 4°C between 2–21 days and for future use below −18°C.
Shelf Life (sealed)	24 months from manufacturing date. Protect from light.